ABSTRACT
Estudo de coorte contemporânea com corte transversal. As diferenças histológicas dos pólipos nasais e a sua possível implicação clínica são escassas em literatura, apesar de sua importância para um diagnóstico preciso. Os trabalhos existentes classificam amostras de pólipos sem a preocupação quanto à influência de tratamentos prévios, o que influenciaria o resultado obtido. OBJETIVO: Estudar morfologicamente, através da microscopia ótica, as alterações estruturais do pólipo nasal na ausência de qualquer tratamento prévio e classificá-lo, histologicamente, correlacionando com os estudos de literatura. MATERIAL E MÉTODOS: Foram estudados 89 pacientes com polipose rinossinusal sem tratamento prévio. As amostras dos pólipos foram colhidas por biópsia ambulatorial e analisadas através de microscopia ótica após coloração com hematoxilina e eosina. RESULTADOS: As amostras foram classificadas da seguinte forma: pólipo Edematoso ou Eosinofílico: 65 casos (73 por cento); pólipo Fibroinflamatório: 16 casos (18 por cento); pólipo com Hiperplasia de Glândulas Seromucinosas: 06 casos (6,7 por cento) e pólipo com Atipia de Estroma: 2 casos (2,3 por cento). DISCUSSÃO: O padrão eosinofílico predominou nos pacientes com polipose rinossinusal na população estudada. Este padrão assemelha-se com os principais estudos que, no entanto não mencionam sobre tratamentos prévios. CONCLUSÃO: Após análise das características histológicas dos pólipos, observou-se que pólipos não tratados apresentam um padrão predominantemente eosinofílico.
Contemporary cohort cross-sectional study. Introduction: Despite its importance for an accurate diagnosis, histology differences among nasal polyps and its clinical implications are rarely reported in the literature. The existing papers classify polyp samples without concern for prior treatments, which could influence the results attained. AIMS: carry out a morphological study, through light microscopy, of nasal polyps' structural alterations in the absence of any type of prior treatment and histologically classify it in relation to studies published in the literature. MATERIALS AND METHODS: We studied 89 patients with nasosinusal polyps without prior treatment. Polyp samples were collected by outpatient biopsy and analyzed through light microscopy after dyeing with hematoxylin-eosin. RESULTS: Samples were classified in the following way: Edematous or eosinophilic polyp 65 cases (73 percent); fibro-inflammatory polyp: 16 cases (18 percent); Polyp with Sero-mucinose gland hyperplasia: 06 cases (6.7 percent) and polyp with stroma atypia: 2 cases (2.3 percent). DISCUSSION: eosinophilic pattern prevailed in the patients with nasosinusal polyps of the population studied. This pattern is similar to the ones found in the major studies, which, however, do not mention prior treatment. CONCLUSION: after analyzing the polyps' histological characteristics, we noticed that the untreated polyps present a predominantly eosinophilic pattern.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Nasal Polyps/ultrastructure , Paranasal Sinus Diseases/pathology , Paranasal Sinuses/ultrastructure , Biopsy , Chi-Square Distribution , Cohort Studies , Cross-Sectional Studies , Coloring Agents , Eosinophilia/pathology , Hematoxylin , Nasal Polyps/classificationABSTRACT
Las molestias atribuidas a obstrucción nasal son causa frecuente de consulta, los pediatras deben pensar primero en las etiologías más frecuentes como infección respiratoria alta y alergias, pero no olvidar considerar patologías menos frecuentes como poliposis nasal. En este artículo se realiza una revisión del tema para orientar su correcta sospecha y diagnóstico.
Subject(s)
Humans , Child , Nasal Polyps/diagnosis , Nasal Polyps/therapy , Nasal Polyps/classification , Nasal Polyps/etiologyABSTRACT
Endoscopic sinus surgery has become a widely accepted surgical procedure for the treatment of chronic inflammatory sinus diseases. In our study 100 patients were suffering from polyposis treated by functional endoscopic sinus surgery in MMCH. Out of 100 patients 53 patients were suffering from ethmoidal polyp and 47 patients were suffering from antrochoanal polyp between the ages 7 to 45 years. Among antrochoanal polyp 2 patients were found with inverted papilloma and came with recurrence. 40% of the patients came with a follow up visit up to 1 year. 7 out of 53 cases of ethmoidal patient came with recurrence requiring revision FESS. There was no history of patient suffering from asthma or aspirin intolerance. Overall success rate was observed in 91%. Four patients were found with periorbital haematoma and 5 with fat coming out from orbit due to injury of lamina papyraceae.
Subject(s)
Adolescent , Adult , Child , Chronic Disease , Endoscopy/methods , Female , Humans , Male , Middle Aged , Nasal Obstruction/surgery , Nasal Polyps/classification , Paranasal Sinus Diseases/complications , Recurrence , Sphenoid Bone/surgeryABSTRACT
Material and methods 20 patients with nasal polyps were successively studied. Personal and familiar history of atopy, evolution time, previous surgery, asthmatic crises, medication received, total IgE general and local eosiniphylia skin tests with inhalers, challenge tests with AAS and metacholine test were studied. Surgery was perfomed, histopathologic studies (hematoxylin eosin) and immunoperoxidases for IgG, IgM, IgA, IgE on sections were done. After this early study, patients were divided into 3 groups: group I: patients without brochial hyperreactivity (HRB (-)) without sensitivity to AAS (AAS(-)); Group II: patients HRG (+) AAS (-); Group III: patients HRG(+) AAS(+). Those patients with previous rhinoscopy and with hyperreactivity to metacholine were examined monthly during one year: their symptoms and medication, 3 patients from group II and 3 from Group III were selected. Half of them were prescribed beclomethasone, and the other half, beclomethasone + dexamethasone dipropionate cream locally applied